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One of the thrust areas of research at ACBR, is the field of medicinal chemistry. This particular field of study encompasses the study of synthetic organic chemistry on one hand to natural product chemistry, biochemistry, computational chemistry and physiology on the other. The mechanisms by which drugs/ligands interact with specific receptors is the focus of research in this area. These drugs may elicit & response by acting as agonists or antagonists. Research is being carried out in several interrelated areas of medicinal chemistry, at ACBR.
1. A dual approach is being undertaken to find possible le drugs to combat Alzheimer's disease. Substituted 1, 2, 4 -oxadiazoles and substituted diphenyl sulphoxides, which act as M1 receptor agonists and M2 receptor antagonists, respectively, are being synthesized and their activity tested.
2. The uses of the medicinal plant Ashwagandha are being studied in relation to their anti-stress activity as are the molecular mechanisms underlying the action of their active principles.
3. A group of research scientists is working on the design, synthesis and optimization of suitable non-peptidic quinazolinone derivatives as specific antagonists for CCK-B/gastrin receptors. The quinazolinones will be radiolabelled with 99m Tc and will ultimately be used as a probe to target and treat malignant tumors.
4. Work is being carried out on designing and synthesizing some novel non-covalently binding anti-cancer and anti tumor agents. The molecular mechanisms of these drugs are being studied using physico-chemical and biological techniques involving leukemia cell lines and synthetic oligonucleotides. Recently research has been initiated to study the triple-helix stabilization using these anti-cancer agents, as ligands.
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